Yuvaraja's College started functioning in the year 1928. Initially only the two year intermediate course was offered with optional subjects like Botany, Zoology and Chemistry.  From 1948 onwards 3-year degree course was started.  The University of Mysore with the idea of diversification introduced new courses.  Biochemistry was one among them. Biochemistry was started as the major subject of the B.Sc., course in the Department of chemistry, Yuvaraja’s college in 1980.
            Later the Biochemistry department was separated from the chemistry department in the year 2000 and started working independently under the headship of Dr. A.C. Sharada. A separate Biochemistry laboratory was established at YCM in 2003. The laboratory is well equipped with all the necessary basic facilities for the undergraduate teaching. The laboratory runs from all the week days from 7:30 AM to 6 PM to cater the needs of 360 students belonging to I, II, III B.Sc., and five year integrated M.Sc., Molecular  Biology.
Through the years the department has grown in terms of student strength. Initially the admission was for the combinations BBM, BBZ and BZF. The number of students seeking admissions is gradually increasing with the introduction of new combination BMBt. The Biochemistry section of the University under Graduate library is quite well stocked and thus full fills the needs of both teachers and students. Restructuring of the syllabus is done once in three years at national level.
The department has staff strength of six teachers with three permanent, one temporary and two guest lecturers. Two of the permanent faculty of the department are Ph.D., holders and have publications in National and International Journals. Dr A.C Sharada, Selection grade Lecturer has 23 years of teaching and research experience and is currently heading the department. Dr. J. Rajesh, Senior scale lecturer has seven years of teaching experience and has obtained Ph.D., through faculty improvement program. Dr. Rajesh was awarded PDF in USA and has presented a paper in international conference during Sept. 2008. Mr. M.A. Harish Nayaka, Lecturer is having three years of teaching experience and is now working for his Ph.D., through faculty improvement program. 

Dr. A.C. Sharada and Dr. J. Rajesh are recognized as research guides. Dr. ACS is presently supervising the research work of two Ph. D., candidates. The other teachers are also pursuing research in Biochemistry. The lecturers have attended conferences, seminars and workshop of interest and related to their field.
The faculties of the Department are the members of Society of Biological Chemist, CFRTI, Mysore and Association of Food Science and Technology of India, CFTRI, Mysore. Through the society, lectures by eminent speakers on topics of general interests and subject are arranged for the students and staff of the college. The students are encouraged and trained to participate in the various competitions conducted by the above society and have won the prizes. Alumni students have been placed at higher position in various laboratories in India and abroad.